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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but They are really unusual Within this malignancy compared to other lymphoid neoplasms. CHD2 is mutated in 5% of CLL and 7% of MBL.75 The histone methyltransferase SETD2 and ARID1A will also be mutated in a little proportion of people. Of Take note, MYD88 mutations and trisomy 12 are connected with specific reworking of chromatin activation and accessibility areas.
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